Diagnosis of asymptomatic and low-parasitemia infections, G6PD testing, non-invasive sampling, and AI-assisted microscopy. This session will focus on advances in diagnostic approaches and implementation strategies that improve detection sensitivity and accessibility, particularly in low-transmission and hard-to-reach settings. Advances in omics-based approaches for diagnostics, including multiplex assays and novel detection platforms, will also be considered.

Advances in omics-based approaches, such as single-cell analysis, next-generation serology, multiplex assays, high-throughput sequencing and their integration into real-time molecular and serological surveillance for control and elimination strategies. Applications of molecular and genomic surveillance and implementation strategies to understand transmission dynamics, population genetics and structure, and the emergence of zoonotic malaria.

Progress in novel therapeutics, including radical cure strategies among vulnerable populations (children and pregnant women). Recent advances in antimalarial drug development, updates on clinical trials for new drug combinations, and current evidence of antimalarial drug resistance, together with implementation strategies to support their effective deployment in endemic settings.

The latest insights into hypnozoite biology, the mechanisms underlying relapse, and the role of immune modulation in recurrent infection. Advances in the identification of hypnozoite biomarkers and new human challenge models and their implications for relapse research. Expanding the concept of hidden reservoirs to include cryptic blood-stage parasite niches and their role in persistence, transmission, and treatment response.

Latest findings on the molecular and immunological interactions between P. vivax and the human host. New approaches to target invasion mechanisms, parasite adaptation to the Duffy-negative phenotype, and modulate immune responses. Recent advances in malaria in pregnancy and severe P. vivax malaria.

In-depth exploration of natural immunity to P. vivax, including B- and T-cell responses and antibody-mediated mechanisms. The role of asymptomatic carriers in immune priming and maintenance of transmission reservoirs, as well as malaria in pregnancy, including the dynamics of infection during gestation, transmission from pregnant women to newborns, and its impact on early-life immunity. Implications of these findings for the next generation of P. vivax vaccine development.

Development of advanced model systems for studying P. vivax, including organoids, animal models, and humanized models. Implications for drug testing and understanding parasite biology in vivo.

Ecological and climate drivers of P. vivax transmission, including environmental and climatic determinants of transmission dynamics, vector–parasite–host interactions, and spatial and temporal transmission patterns. Integration of climate-driven mathematical models and disease modeling approaches for early warning systems predicting transmission expansion.

Understanding the biology, behavior, and ecological dynamics of malaria vectors, from field surveys to molecular approaches. Latest findings on the interaction between P. vivax and mosquito hosts. The spread of Anopheles stephensi into new ecological settings in Africa and its implications for malaria transmission. Role of the mosquito microbiome in vector competence and emerging entomological surveillance tools.